Peptic ulcer being one of the most rampant gastrointestinal disorders continues to occupy the key position in concern of researchers. Unfortunately most of the drugs used to treat this confer simple to sever side effects like arrythmias, gynacomastia, and heamotopoeitic changes. In this context our research was focused on recent herbal initiative piperine, proposed to be used in treating the gastric ulcers. Floating beads of piperine were prepared by using natural polymer sodium alginate by following ionotropic gellation method with the inclusion of gas liberating agents and swelling polymer. They were evaluated for various floating properties and drug release properties. The percentage yield was found to be around 75%. Swelling ratio was found to be 85% to 132% and the drug encapsulation efficiency was 65% to 81%. Percent cumulative drug release was found to be from 68 to 95%. The floatation time is more than 12 h. The results were encouraging as our formulation contains indigenous drug with fewer side effects to have a better and safer alternative treatment for peptic ulcer.
Loading....